Lineage for d1sp4.1 (1sp4 A:,B:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2154577Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2154578Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 2154579Family d.3.1.1: Papain-like [54002] (26 protein domains)
  6. 2154580Protein (Pro)cathepsin B [54022] (3 species)
  7. 2154581Species Cow (Bos taurus) [TaxId:9913] [54025] (3 PDB entries)
  8. 2154584Domain d1sp4.1: 1sp4 A:,B: [98956]
    complexed with ep2

Details for d1sp4.1

PDB Entry: 1sp4 (more details), 2.2 Å

PDB Description: Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft
PDB Compounds: (A:) cathepsin b, (B:) cathepsin b

SCOPe Domain Sequences for d1sp4.1:

Sequence; same for both SEQRES and ATOM records: (download)

>g1sp4.1 d.3.1.1 (A:,B:) (Pro)cathepsin B {Cow (Bos taurus) [TaxId: 9913]}

SCOPe Domain Coordinates for d1sp4.1:

Click to download the PDB-style file with coordinates for d1sp4.1.
(The format of our PDB-style files is described here.)

Timeline for d1sp4.1: