SCOP 1.73: Domain d1so2b_: 1so2 B:

Lineage for d1so2b_ (1so2 B:)

1. Root: SCOP 1.73

2. Class a: All alpha proteins [46456] (258 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (5 families)

5. Family a.211.1.2: PDEase [48548] (6 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein cGMP-inhibited 3',5'-cyclic phosphodiesterase B, pde3b [101441] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101442] (2 PDB entries)

8. Domain d1so2b_: 1so2 B: [98937]

Details for d1so2b_

PDB Entry: 1so2, 2.4 Å

PDB Description: catalytic domain of human phosphodiesterase 3b in complex with a dihydropyridazine inhibitor

PDB Compounds: (B:) cGMP-inhibited 3',5'-cyclic phosphodiesterase B

SCOP Domain Sequences for d1so2b_:

Sequence, based on SEQRES records:

>d1so2b_ a.211.1.2 (B:) cGMP-inhibited 3',5'-cyclic phosphodiesterase B, pde3b {Human (Homo sapiens) [TaxId: 9606]}
ldlilveeydsliekmsnwnfpifelvekmgeksgrilsqvmytlfqdtglleifkiptq
qfmnyfralengyrdipyhnrihatdvlhavwylttrpvpglqqihngcgtgnetdsdgr
inhgriayisskscsnpdesygclssnipalelmalyvaaamhdydhpgrtnaflvatna
pqavlyndrsvlenhhaasawnlylsrpeynfllhldhvefkrfrflvieailatdlkkh
fdflaefnakandvnsngiewsnendrllvcqvcikladingpakvrdlhlkwtegivne
fyeqgdeeanlglpispfmdrsspqlaklqesfithivgplcnsydaagllpgqwleaee
dndtesgddedgeeldtedeemennlnpkpprrksrrrifcqlmhhltenhkiwk

Sequence, based on observed residues (ATOM records):

>d1so2b_ a.211.1.2 (B:) cGMP-inhibited 3',5'-cyclic phosphodiesterase B, pde3b {Human (Homo sapiens) [TaxId: 9606]}
ldlilveeydsliekmsnwnfpifelvekmgeksgrilsqvmytlfqdtglleifkiptq
qfmnyfralengyrdipyhnrihatdvlhavwylttrpvpglqqihnggriayisskscs
npdesygclssnipalelmalyvaaamhdydhpgrtnaflvatnapqavlyndrsvlenh
haasawnlylsrpeynfllhldhvefkrfrflvieailatdlkkhfdflaefnakandvn
sngiewsnendrllvcqvcikladingpakvrdlhlkwtegivnefyeqgdeeanlglpi
spfmdrsspqlaklqesfithivgplcnsydaagllpgqwlesrrrifcqlmhhltenhk
iwk

Timeline for d1so2b_:

• d1so2b_ first appeared in SCOP 1.67
  
• d1so2b_ appears in SCOP 1.71
  
• d1so2b_ appears in SCOP 1.75
  
• d1so2b_ appears in the current release, SCOPe 2.08