SCOP 1.73: Domain d1s7ga_: 1s7g A:

Lineage for d1s7ga_ (1s7g A:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (6 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (7 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein AF0112, Sir2 homolog (Sir2-AF2) [82380] (1 species)

7. Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [82381] (3 PDB entries)

8. Domain d1s7ga_: 1s7g A: [98642]

Details for d1s7ga_

PDB Entry: 1s7g, 2.3 Å

PDB Description: Structural Basis for the Mechanism and Regulation of Sir2 Enzymes

PDB Compounds: (A:) NAD-dependent deacetylase 2

SCOP Domain Sequences for d1s7ga_:

Sequence; same for both SEQRES and ATOM records:

>d1s7ga_ c.31.1.5 (A:) AF0112, Sir2 homolog (Sir2-AF2) {Archaeon Archaeoglobus fulgidus [TaxId: 2234]}
medeirkaaeilakskhavvftgagisaesgiptfrgedglwrkydpeevasisgfkrnp
rafwefsmemkdklfaepnpahyaiaelermgivkavitqnidmlhqragsrrvlelhgs
mdkldcldchetydwsefvedfnkgeiprcrkcgsyyvkprvvlfgeplpqrtlfeaiee
akhcdafmvvgsslvvypaaelpyiakkagakmiivnaeptmadpifdvkiigkagevlp
kiveevkrlrse

Timeline for d1s7ga_:

• d1s7ga_ first appeared in SCOP 1.67
  
• d1s7ga_ appears in SCOP 1.71
  
• d1s7ga_ appears in SCOP 1.75
  
• d1s7ga_ appears in the current release, SCOPe 2.08