Lineage for d1s3ua_ (1s3u A:)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2477518Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2477519Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2477520Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2477723Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2477771Species Human (Homo sapiens) [TaxId:9606] [53607] (74 PDB entries)
  8. 2477855Domain d1s3ua_: 1s3u A: [98464]
    complexed with so4, tqd

Details for d1s3ua_

PDB Entry: 1s3u (more details), 2.5 Å

PDB Description: structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1s3ua_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1s3ua_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1s3ua_:

Click to download the PDB-style file with coordinates for d1s3ua_.
(The format of our PDB-style files is described here.)

Timeline for d1s3ua_: