SCOP 1.73: Domain d1s1ra_: 1s1r A:

Lineage for d1s1ra_ (1s1r A:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (15 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (10 PDB entries)

8. Domain d1s1ra_: 1s1r A: [98355]
   complexed with act, mpd, nap

Details for d1s1ra_

PDB Entry: 1s1r, 2 Å

PDB Description: Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin

PDB Compounds: (A:) Aldo-keto reductase family 1 member C3

SCOP Domain Sequences for d1s1ra_:

Sequence; same for both SEQRES and ATOM records:

>d1s1ra_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
eelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkyk
pvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcala
kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhy
fnsdsfashpnypysd

Timeline for d1s1ra_:

• d1s1ra_ first appeared in SCOP 1.67
  
• d1s1ra_ appears in SCOP 1.71
  
• d1s1ra_ appears in SCOP 1.75
  
• d1s1ra_ appears in the current release, SCOPe 2.08