SCOPe 2.05: Domain d1rpnd_: 1rpn D:

Lineage for d1rpnd_ (1rpn D:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein GDP-mannose 4,6-dehydratase [51759] (4 species)

7. Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)

8. Domain d1rpnd_: 1rpn D: [97711]
   complexed with gdp, ndp

Details for d1rpnd_

PDB Entry: 1rpn, 2.15 Å

PDB Description: Crystal Structure of GDP-D-mannose 4,6-dehydratase in complexes with GDP and NADPH

PDB Compounds: (D:) GDP-mannose 4,6-dehydratase

SCOPe Domain Sequences for d1rpnd_:

Sequence; same for both SEQRES and ATOM records:

>d1rpnd_ c.2.1.2 (D:) GDP-mannose 4,6-dehydratase {Pseudomonas aeruginosa [TaxId: 287]}
trsalvtgitgqdgaylaklllekgyrvhglvarrssdtrwrlrelgiegdiqyedgdma
dacsvqravikaqpqevynlaaqsfvgaswnqpvttgvvdglgvthlleairqfspetrf
yqastsemfgliqaerqdentpfyprspygvaklyghwitvnyresfglhassgilfnhe
splrgiefvtrkvtdavariklgkqqelrlgnvdakrdwgfagdyveamwlmlqqdkadd
yvvatgvtttvrdmcqiafehvgldyrdflkidpaffrpaevdvllgnpakaqrvlgwkp
rtsldelirmmveadlrrvsre

Timeline for d1rpnd_:

• d1rpnd_ first appeared in SCOP 1.67
  
• d1rpnd_ appears in SCOPe 2.04
  
• d1rpnd_ appears in SCOPe 2.06
  
• d1rpnd_ appears in the current release, SCOPe 2.08