SCOPe 2.08: Domain d1rffa2: 1rff A:351-608

Lineage for d1rffa2 (1rff A:351-608)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.136: Phospholipase D/nuclease [56023] (1 superfamily)
   beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234

4. Superfamily d.136.1: Phospholipase D/nuclease [56024] (6 families)

5. Family d.136.1.3: Tyrosyl-DNA phosphodiesterase TDP1 [69815] (2 proteins)

6. Protein Tyrosyl-DNA phosphodiesterase TDP1 [69816] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69817] (36 PDB entries)

8. Domain d1rffa2: 1rff A:351-608 [97377]
   protein/DNA complex; complexed with spm, vo4

Details for d1rffa2

PDB Entry: 1rff, 1.7 Å

PDB Description: crystal structure of human tyrosyl-dna phosphodiesterase complexed with vanadate, octapeptide klnyydpr, and tetranucleotide agtt.

PDB Compounds: (A:) tyrosyl-DNA phosphodiesterase 1

SCOPe Domain Sequences for d1rffa2:

Sequence, based on SEQRES records:

>d1rffa2 d.136.1.3 (A:351-608) Tyrosyl-DNA phosphodiesterase TDP1 {Human (Homo sapiens) [TaxId: 9606]}
nvyligstpgrfqgsqkdnwghfrlkkllkdhassmpnaeswpvvgqfssvgslgadesk
wlcsefkesmltlgkesktpgkssvplyliypsvenvrtslegypaggslpysiqtaekq
nwlhsyfhkwsaetsgrsnamphiktymrpspdfskiawflvtsanlskaawgalekngt
qlmirsyelgvlflpsalgldsfkvkqkffagsqepmatfpvpydlppelygskdrpwiw
nipyvkapdthgnmwvps

Sequence, based on observed residues (ATOM records):

>d1rffa2 d.136.1.3 (A:351-608) Tyrosyl-DNA phosphodiesterase TDP1 {Human (Homo sapiens) [TaxId: 9606]}
nvyligstpgrfqgsqkdnwghfrlkkllkdhassmswpvvgqfssvgslgadeskwlcs
efkesmltlgvplyliypsvenvrtslegypaggslpysiqtaekqnwlhsyfhkwsaet
sgrsnamphiktymrpspdfskiawflvtsanlskaawgalekngtqlmirsyelgvlfl
psalgldsfkvkqkfatfpvpydlppelygskdrpwiwnipyvkapdthgnmwvps

Timeline for d1rffa2:

• d1rffa2 first appeared in SCOP 1.67
  
• d1rffa2 appears in SCOPe 2.07