SCOPe 2.07: Domain d1r6ub_: 1r6u B:

Lineage for d1r6ub_ (1r6u B:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
   core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.26.1: Nucleotidylyl transferase [52374] (6 families)

5. Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain [52375] (13 proteins)
   contains a conserved all-alpha subdomain at the C-terminal extension

6. Protein Tryptophanyl-tRNA synthetase (TrpRS) [52378] (5 species)
   overall structure is similar to TyrRS

7. Species Human (Homo sapiens) [TaxId:9606] [102256] (13 PDB entries)
   Uniprot P23381 94-471

8. Domain d1r6ub_: 1r6u B: [97164]
   complexed with gol, tym

Details for d1r6ub_

PDB Entry: 1r6u, 2 Å

PDB Description: crystal structure of an active fragment of human tryptophanyl-trna synthetase with cytokine activity

PDB Compounds: (B:) Tryptophanyl-tRNA synthetase

SCOPe Domain Sequences for d1r6ub_:

Sequence, based on SEQRES records:

>d1r6ub_ c.26.1.1 (B:) Tryptophanyl-tRNA synthetase (TrpRS) {Human (Homo sapiens) [TaxId: 9606]}
gidydklivrfgsskidkelinrieratgqrphhflrrgiffshrdmnqvldayenkkpf
ylytgrgpsseamhvghlipfiftkwlqdvfnvplviqmtddekylwkdltldqaygdav
enakdiiacgfdinktfifsdldymgmssgfyknvvkiqkhvtfnqvkgifgftdsdcig
kisfpaiqaapsfsnsfpqifrdrtdiqclipcaidqdpyfrmtrdvaprigypkpallh
stffpalqgaqtkmsasdpnssifltdtakqiktkvnkhafsggrdtieehrqfggncdv
dvsfmyltffledddkleqirkdytsgamltgelkkalievlqpliaehqarrkevtdei
vkefmtprkls

Sequence, based on observed residues (ATOM records):

>d1r6ub_ c.26.1.1 (B:) Tryptophanyl-tRNA synthetase (TrpRS) {Human (Homo sapiens) [TaxId: 9606]}
gidydklivrfgsskidkelinrieratgqrphhflrrgiffshrdmnqvldayenkkpf
ylytgrgpsseamhvghlipfiftkwlqdvfnvplviqmtddekylwkdltldqaygdav
enakdiiacgfdinktfifsdldymgmssgfyknvvkiqkhvtfnqvkgifgftdsdcig
kisfpaiqaapsfsnsfpqifrdrtdiqclipcaidqdpyfrmtrdvaprigypkpallh
stffpalqgpnssifltdtakqiktkvnkhafsggrdtieehrqfggncdvdvsfmyltf
fledddkleqirkdytsgamltgelkkalievlqpliaehqarrkevtdeivkefmtprk
ls

Timeline for d1r6ub_:

• d1r6ub_ first appeared in SCOP 1.67
  
• d1r6ub_ appears in SCOPe 2.06
  
• d1r6ub_ appears in the current release, SCOPe 2.08