SCOP 1.75: Domain d1r4sa2: 1r4s A:137-296

Lineage for d1r4sa2 (1r4s A:137-296)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.96: T-fold [55619] (2 superfamilies)
   beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
   tunnel-shaped: its known members form wide oligomeric barrels different sizes

4. Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (4 families)
   bind purine or pterin in topologically similar sites between subunits

5. Family d.96.1.4: Urate oxidase (uricase) [55633] (1 protein)

6. Protein Urate oxidase (uricase) [55634] (3 species)
   duplication: one subunit consists of two domains of this fold; beta-sheets of two subunits form a barrel, closed: n=16, S=16

7. Species Aspergillus flavus [TaxId:5059] [55635] (22 PDB entries)

8. Domain d1r4sa2: 1r4s A:137-296 [97046]
   complexed with fcy, mua

Details for d1r4sa2

PDB Entry: 1r4s, 1.8 Å

PDB Description: urate oxidase from aspergillus flavus complexed with its inhibitor 9- methyl uric acid

PDB Compounds: (A:) Uricase

SCOP Domain Sequences for d1r4sa2:

Sequence; same for both SEQRES and ATOM records:

>d1r4sa2 d.96.1.4 (A:137-296) Urate oxidase (uricase) {Aspergillus flavus [TaxId: 5059]}
gkgidiksslsgltvlkstnsqfwgflrdeyttlketwdrilstdvdatwqwknfsglqe
vrshvpkfdatwatarevtlktfaednsasvqatmykmaeqilarqqlietveyslpnkh
yfeidlswhkglqntgknaevfapqsdpnglikctvgrss

Timeline for d1r4sa2:

• d1r4sa2 first appeared in SCOP 1.67
  
• d1r4sa2 appears in SCOP 1.73
  
• d1r4sa2 appears in SCOPe 2.01
  
• d1r4sa2 appears in the current release, SCOPe 2.08