SCOP 1.69: Domain d1r4mc_: 1r4m C:

Lineage for d1r4mc_ (1r4m C:)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (2 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
   the common fold is elaborated with additional (sub)domains

6. Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

7. Species Human (Homo sapiens) [TaxId:9606] [89767] (4 PDB entries)

8. Domain d1r4mc_: 1r4m C: [97001]
   Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_

Details for d1r4mc_

PDB Entry: 1r4m, 3 Å

PDB Description: appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex

SCOP Domain Sequences for d1r4mc_:

Sequence, based on SEQRES records:

>d1r4mc_ c.111.1.2 (C:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens)}
kllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqv
sgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftv
vvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrl
dkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykekedfrd
lirqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilara
lkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigq
apesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlr
avdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaep
htiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

Sequence, based on observed residues (ATOM records):

>d1r4mc_ c.111.1.2 (C:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens)}
kllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqv
sgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftv
vvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrl
dkpfpelrehfqsydhshtpwiviiakylaqwysetngripktykekedfrdlirqgilk
pedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilaralkefvake
gqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqapesisek
elkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlravdrfhkq
qgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaephtiaaflg
gaaaqevikiitkqfvifnntyiysgmsqtsatfql

Timeline for d1r4mc_:

• d1r4mc_ first appeared in SCOP 1.67
  
• d1r4mc_ appears in SCOP 1.71
  
• d1r4mc_ appears in the current release, SCOPe 2.08