SCOPe 2.04: Domain d1r2ja2: 1r2j A:3-212

Lineage for d1r2ja2 (1r2j A:3-212)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily)
   2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology

4. Superfamily e.6.1: Acyl-CoA dehydrogenase NM domain-like [56645] (3 families)
   flavoprotein: binds FAD; constituent families differ in the numbers of C-terminal domains (four-helical bundles)

5. Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [56646] (10 proteins)

6. Protein Protein FkbI [103396] (1 species)
   involved in biosynthesis of methoxymalonyl extender unit of fk520 polyketide immunosuppressant

7. Species Streptomyces hygroscopicus [TaxId:1912] [103397] (1 PDB entry)

8. Domain d1r2ja2: 1r2j A:3-212 [96870]
   Other proteins in same PDB: d1r2ja1
   complexed with fad

Details for d1r2ja2

PDB Entry: 1r2j, 2.1 Å

PDB Description: fkbi for biosynthesis of methoxymalonyl extender unit of fk520 polyketide immunosuppresant

PDB Compounds: (A:) protein FkbI

SCOPe Domain Sequences for d1r2ja2:

Sequence, based on SEQRES records:

>d1r2ja2 e.6.1.1 (A:3-212) Protein FkbI {Streptomyces hygroscopicus [TaxId: 1912]}
erdalltdlvgdraaewdtsgelprdllvrlgadgllcaevaaehgglglgsrengefta
hvgslcsslrsvmtsqgmaawtvqrlgdagqratflkeltsgklaavgfserqagsdlsa
mrtrvrldgdtavvdghkvwttaaayadhlvvfglqedgsgavvvvpadtpgvrvervpk
psgcraaghadlhldqvrvpagavlagsga

Sequence, based on observed residues (ATOM records):

>d1r2ja2 e.6.1.1 (A:3-212) Protein FkbI {Streptomyces hygroscopicus [TaxId: 1912]}
erdalltdlvgdraaewdtsgelprdllvrlgadgllcaevaaehgglglgsrengefta
hvgslcsslrsvmtsqgmaawtvqrlgdagqratflkeltsglaavgfserqagsdlsam
rtrvrldgdtavvdghkvwttaaayadhlvvfglqedgsgavvvvpadtpgvrvervpkp
sgcraaghadlhldqvrvpagavlagsga

Timeline for d1r2ja2:

• d1r2ja2 first appeared in SCOP 1.67
  
• d1r2ja2 appears in SCOPe 2.03
  
• d1r2ja2 appears in SCOPe 2.05
  
• d1r2ja2 appears in the current release, SCOPe 2.08