SCOPe 2.08: Domain d1r2ia_: 1r2i A:

Lineage for d1r2ia_ (1r2i A:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein Apoptosis regulator Bcl-xL [56856] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56857] (51 PDB entries)

8. Domain d1r2ia_: 1r2i A: [96868]
   mutant

Details for d1r2ia_

PDB Entry: 1r2i, 2 Å

PDB Description: human bcl-xl containing a phe to leu mutation at position 146

PDB Compounds: (A:) apoptosis regulator bcl-x

SCOPe Domain Sequences for d1r2ia_:

Sequence, based on SEQRES records:

>d1r2ia_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens) [TaxId: 9606]}
msqsnrelvvdflsyklsqkgyswsqfsdveenrteapegtesemetpsaingnpswhla
dspavngatghsssldarevipmaavkqalreagdefelryrrafsdltsqlhitpgtay
qsfeqvvnelfrdgvnwgrivaffslggalcvesvdkemqvlvsriaawmatylndhlep
wiqenggwdtfvelygn

Sequence, based on observed residues (ATOM records):

>d1r2ia_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens) [TaxId: 9606]}
msqsnrelvvdflsyklsqkgyswsqfpmaavkqalreagdefelryrrafsdltsqlhi
tpgtayqsfeqvvnelfrdgvnwgrivaffslggalcvesvdkemqvlvsriaawmatyl
ndhlepwiqenggwdtfvelygn

Timeline for d1r2ia_:

• d1r2ia_ first appeared in SCOP 1.67
  
• d1r2ia_ appears in SCOPe 2.07