SCOP 1.69: Domain d1r2ha_: 1r2h A:

Lineage for d1r2ha_ (1r2h A:)

1. Root: SCOP 1.69

2. Class f: Membrane and cell surface proteins and peptides [56835] (47 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (1 family)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (8 proteins)

6. Protein Apoptosis regulator Bcl-xL [56856] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56857] (9 PDB entries)

8. Domain d1r2ha_: 1r2h A: [96867]

Details for d1r2ha_

PDB Entry: 1r2h, 2.2 Å

PDB Description: human bcl-xl containing an ala to leu mutation at position 142

SCOP Domain Sequences for d1r2ha_:

Sequence, based on SEQRES records:

>d1r2ha_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens)}
msqsnrelvvdflsyklsqkgyswsqfsdveenrteapegtesemetpsaingnpswhla
dspavngatghsssldarevipmaavkqalreagdefelryrrafsdltsqlhitpgtay
qsfeqvvnelfrdgvnwgrivlffsfggalcvesvdkemqvlvsriaawmatylndhlep
wiqenggwdtfvelyg

Sequence, based on observed residues (ATOM records):

>d1r2ha_ f.1.4.1 (A:) Apoptosis regulator Bcl-xL {Human (Homo sapiens)}
msqsnrelvvdflsyklsqkgyswsqfpmaavkqalreagdefelryrrafsdltsqlhi
tpgtayqsfeqvvnelfrdgvnwgrivlffsfggalcvesvdkemqvlvsriaawmatyl
ndhlepwiqenggwdtfvelyg

Timeline for d1r2ha_:

• d1r2ha_ first appeared in SCOP 1.67
  
• d1r2ha_ appears in SCOP 1.71
  
• d1r2ha_ appears in the current release, SCOPe 2.08