SCOPe 2.05: Domain d1r10a_: 1r10 A:

Lineage for d1r10a_ (1r10 A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (24 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology

6. Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [102379] (9 PDB entries)
   Uniprot P26361 390-670

8. Domain d1r10a_: 1r10 A: [96770]
   complexed with acy, atp, mg

Details for d1r10a_

PDB Entry: 1r10, 3 Å

PDB Description: cystic fibrosis transmembrane conductance regulator (cftr) nucleotide- binding domain one (nbd1) with atp, i4122 space group

PDB Compounds: (A:) Cystic fibrosis transmembrane conductance regulator

SCOPe Domain Sequences for d1r10a_:

Sequence, based on SEQRES records:

>d1r10a_ c.37.1.12 (A:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Mouse (Mus musculus) [TaxId: 10090]}
giimenvtafweegfgellekvqqsngdrkhssdennvsfshlclvgnpvlkninlniek
gemlaitgstgsgktsllmlilgeleasegiikhsgrvsfcsqfswimpgtikeniifgv
sydeyryksvvkacqlqqditkfaeqdntvlgeggvtlsggqrarislaravykdadlyl
ldspfgyldvfteeqvfescvcklmanktrilvtskmehlrkadkililhqgssyfygtf
selqslrpdfssklmgydtfdqfteerrssiltetlrrfs

Sequence, based on observed residues (ATOM records):

>d1r10a_ c.37.1.12 (A:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Mouse (Mus musculus) [TaxId: 10090]}
giimenvtafweegfgellekvsfshlclvgnpvlkninlniekgemlaitgstgsgkts
llmlilgeleasegiikhsgrvsfcsqfswimpgtikeniifgvsydeyryksvvkacql
qqditkfaeqdntvlgeggvtlsggqrarislaravykdadlylldspfgyldvfteeqv
fescvcklmanktrilvtskmehlrkadkililhqgssyfygtfselqslrpdfssklmg
ydtfdqfteerrssiltetlrrfs

Timeline for d1r10a_:

• d1r10a_ first appeared in SCOP 1.67
  
• d1r10a_ appears in SCOPe 2.04
  
• d1r10a_ appears in SCOPe 2.06
  
• d1r10a_ appears in the current release, SCOPe 2.08