SCOPe 2.06: Domain d1qzfb2: 1qzf B:181-521

Lineage for d1qzfb2 (1qzf B:181-521)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)

8. Domain d1qzfb2: 1qzf B:181-521 [96636]
   Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
   complexed with cb3, fol, ndp, ump

Details for d1qzfb2

PDB Entry: 1qzf, 2.8 Å

PDB Description: Crystal structure of DHFR-TS from Cryptosporidium hominis

PDB Compounds: (B:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d1qzfb2:

Sequence; same for both SEQRES and ATOM records:

>d1qzfb2 d.117.1.1 (B:181-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

Timeline for d1qzfb2:

• d1qzfb2 first appeared in SCOP 1.67
  
• d1qzfb2 appears in SCOPe 2.05
  
• d1qzfb2 appears in SCOPe 2.07
  
• d1qzfb2 appears in the current release, SCOPe 2.08