SCOP 1.73: Domain d1qzfb1: 1qzf B:3-180

Lineage for d1qzfb1 (1qzf B:3-180)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [102636] (2 PDB entries)

8. Domain d1qzfb1: 1qzf B:3-180 [96635]
   Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2

Details for d1qzfb1

PDB Entry: 1qzf, 2.8 Å

PDB Description: Crystal structure of DHFR-TS from Cryptosporidium hominis

PDB Compounds: (B:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOP Domain Sequences for d1qzfb1:

Sequence; same for both SEQRES and ATOM records:

>d1qzfb1 c.71.1.1 (B:3-180) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Cryptosporidium hominis [TaxId: 237895]}
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek

Timeline for d1qzfb1:

• d1qzfb1 first appeared in SCOP 1.67
  
• d1qzfb1 appears in SCOP 1.71
  
• d1qzfb1 appears in SCOP 1.75
  
• d1qzfb1 appears in the current release, SCOPe 2.08