SCOPe 2.05: Domain d1qxpa4: 1qxp A:2-355

Lineage for d1qxpa4 (1qxp A:2-355)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)
   automatically mapped to Pfam PF00648

6. Protein Calpain large subunit, catalytic domain (domain II) [54041] (6 species)
   includes the N-terminal 'sequence' domain I

7. Species Norway rat (Rattus norvegicus), mu-type [TaxId:10116] [75332] (10 PDB entries)
   Uniprot P97571 33-353

8. Domain d1qxpa4: 1qxp A:2-355 [96546]
   Other proteins in same PDB: d1qxpa1, d1qxpa2, d1qxpa3, d1qxpb1, d1qxpb2, d1qxpb3
   mu-like isoform with the large and small subunits fused in a single chain

Details for d1qxpa4

PDB Entry: 1qxp, 2.8 Å

PDB Description: crystal structure of a mu-like calpain

PDB Compounds: (A:) mu-like calpain

SCOPe Domain Sequences for d1qxpa4:

Sequence, based on SEQRES records:

>d1qxpa4 d.3.1.3 (A:2-355) Calpain large subunit, catalytic domain (domain II) {Norway rat (Rattus norvegicus), mu-type [TaxId: 10116]}
agiamklakdreaaeglgsheraikylnqdyetlrnecleagalfqdpafppvshslgfk
elgpnssktygikwkrptellsnpqfivdgatrtdicqgalgdswllaaiasltlnetil
hrvvpygqsfqegyagifhfqlwqfgewvdvvvddllptkdgklvfvhsaqgnefwsall
ekayakvngsyealsggctseafedftggvtewydlqkapsdlyqiilkalergsllgcs
inisdirdleaitfknlvrghaysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdns
yewnkvdpyereqlrvkmedgefwmsfrdfireftkleicnltpdalksrtlrn

Sequence, based on observed residues (ATOM records):

>d1qxpa4 d.3.1.3 (A:2-355) Calpain large subunit, catalytic domain (domain II) {Norway rat (Rattus norvegicus), mu-type [TaxId: 10116]}
agiamklakdreaaeglgsheraikylnqdyetlrnecleagalfqdpafppvshslgfk
elgpnssktygikwkrptellsnpqfivdgatrtdicqgalgdswllaaiasltlnetil
hrvvpygqsfqegyagifhfqlwqfgewvdvvvddllptkdgklvfvhsaqgnefwsall
ekayakvngsyealsggctseafedftggvtewydlqkapsdlyqiilkalergsllgcs
initfknlhaysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsnsyewnkvdpyereq
lrvkmedgefwmsfrdfireftkleicnltplksrtlrn

Timeline for d1qxpa4:

• d1qxpa4 first appeared in SCOP 1.67
  
• d1qxpa4 appears in SCOPe 2.04
  
• d1qxpa4 appears in SCOPe 2.06
  
• d1qxpa4 appears in the current release, SCOPe 2.08