SCOPe 2.03: Domain d1q14a_: 1q14 A:

Lineage for d1q14a_ (1q14 A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein Hst2 [102294] (1 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [102295] (5 PDB entries)
   Uniprot P53686 1-293

8. Domain d1q14a_: 1q14 A: [95537]
   complexed with cl, zn

Details for d1q14a_

PDB Entry: 1q14, 2.5 Å

PDB Description: Structure and autoregulation of the yeast Hst2 homolog of Sir2

PDB Compounds: (A:) HST2 protein

SCOPe Domain Sequences for d1q14a_:

Sequence, based on SEQRES records:

>d1q14a_ c.31.1.5 (A:) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
gmasmsvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnla
rlklpypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqn
idtlerqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgel
vkpaivffgedlpdsfsetwlndsewlrekittsgkhpqqplvivvgtslavypfaslpe
eiprkvkrvlcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekiltaqgg
mgdnskeqlleivhdlen

Sequence, based on observed residues (ATOM records):

>d1q14a_ c.31.1.5 (A:) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
gmasmsvstastemsvrkiaahmksnpnakvifmvgagistscglarlklpypeavfdvd
ffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqnidtlerqagvkddl
iieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelvkpaivffgedlpd
sfsetwlndsewlrekqqplvivvgtslavypfaslpeeiprkvkrvlcnletvgdfkan
krptdlivhqysdefaeqlveelgwqedfekiltaqkeqlleivhdlen

Timeline for d1q14a_:

• d1q14a_ first appeared in SCOP 1.67
  
• d1q14a_ appears in SCOPe 2.02
  
• d1q14a_ appears in SCOPe 2.04
  
• d1q14a_ appears in the current release, SCOPe 2.08, called d1q14a1