SCOPe 2.06: Domain d1py2d_: 1py2 D:

Lineage for d1py2d_ (1py2 D:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-2 (IL-2) [47301] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47302] (16 PDB entries)

8. Domain d1py2d_: 1py2 D: [95322]
   complexed with a small molecule inhibitor
   complexed with frh, zn

Details for d1py2d_

PDB Entry: 1py2, 2.8 Å

PDB Description: Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2

PDB Compounds: (D:) interleukin-2

SCOPe Domain Sequences for d1py2d_:

Sequence, based on SEQRES records:

>d1py2d_ a.26.1.2 (D:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwitfc
qsiistl

Sequence, based on observed residues (ATOM records):

>d1py2d_ a.26.1.2 (D:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqrprdlisninvivlelkgettfmceyadetativeflnrwitfcqsiistl

Timeline for d1py2d_:

• d1py2d_ first appeared in SCOP 1.67
  
• d1py2d_ appears in SCOPe 2.05
  
• d1py2d_ appears in SCOPe 2.07
  
• d1py2d_ appears in the current release, SCOPe 2.08