Lineage for d1py2a_ (1py2 A:)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2315782Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 2315783Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 2315881Family a.26.1.2: Short-chain cytokines [47286] (14 protein domains)
  6. 2315940Protein Interleukin-2 (IL-2) [47301] (1 species)
  7. 2315941Species Human (Homo sapiens) [TaxId:9606] [47302] (17 PDB entries)
  8. 2315964Domain d1py2a_: 1py2 A: [95319]
    complexed with a small molecule inhibitor
    complexed with frh, zn

Details for d1py2a_

PDB Entry: 1py2 (more details), 2.8 Å

PDB Description: Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2
PDB Compounds: (A:) interleukin-2

SCOPe Domain Sequences for d1py2a_:

Sequence, based on SEQRES records: (download)

>d1py2a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d1py2a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1py2a_:

Click to download the PDB-style file with coordinates for d1py2a_.
(The format of our PDB-style files is described here.)

Timeline for d1py2a_: