SCOP 1.75: Domain d1pxxd1: 1pxx D:3074-3583

Lineage for d1pxxd1 (1pxx D:3074-3583)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.93: Heme-dependent peroxidases [48112] (1 superfamily)
   multihelical; consists of two all-alpha domains

4. Superfamily a.93.1: Heme-dependent peroxidases [48113] (3 families)

5. Family a.93.1.2: Myeloperoxidase-like [48132] (2 proteins)

6. Protein Prostaglandin H2 synthase [48136] (2 species)
   contains EGF-like module

7. Species Mouse (Mus musculus) [TaxId:10090] [48138] (8 PDB entries)

8. Domain d1pxxd1: 1pxx D:3074-3583 [95313]
   Other proteins in same PDB: d1pxxa2, d1pxxb2, d1pxxc2, d1pxxd2
   complexed with bog, dif, hem, nag

Details for d1pxxd1

PDB Entry: 1pxx, 2.9 Å

PDB Description: crystal structure of diclofenac bound to the cyclooxygenase active site of cox-2

PDB Compounds: (D:) Prostaglandin G/H synthase 2

SCOP Domain Sequences for d1pxxd1:

Sequence; same for both SEQRES and ATOM records:

>d1pxxd1 a.93.1.2 (D:3074-3583) Prostaglandin H2 synthase {Mouse (Mus musculus) [TaxId: 10090]}
fltriklllkptpntvhyilthfkgvwnivnnipflrslimkyvltsrsylidspptynv
hygyksweafsnlsyytralppvaddcptpmgvkgnkelpdskevlekvllrrefipdpq
gsnmmfaffaqhfthqffktdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgkl
kyqviggevypptvkdtqvemiypphipenlqfavgqevfglvpglmmyatiwlrehnrv
cdilkqehpewgdeqlfqtsrliligetikiviedyvqhlsgyhfklkfdpellfnqqfq
yqnriasefntlyhwhpllpdtfniedqeysfkqflynnsillehgltqfvesftrqiag
rvaggrnvpiavqavakasidqsremkyqslneyrkrfslkpytsfeeltgekemaaelk
alysdidvmelypallvekprpdaifgetmvelgapfslkglmgnpicspqywkpstfgg
evgfkiintasiqslicnnvkgcpftsfnvq

Timeline for d1pxxd1:

• d1pxxd1 first appeared in SCOP 1.67
  
• d1pxxd1 appears in SCOP 1.73
  
• d1pxxd1 appears in SCOPe 2.01
  
• d1pxxd1 appears in the current release, SCOPe 2.08