SCOPe 2.06: Domain d1pwza_: 1pwz A:

Lineage for d1pwza_ (1pwz A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Halohydrin dehalogenase HheC [102153] (1 species)
   haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site

7. Species Agrobacterium tumefaciens [TaxId:358] [102154] (5 PDB entries)

8. Domain d1pwza_: 1pwz A: [95267]
   complexed with cl, rso

Details for d1pwza_

PDB Entry: 1pwz, 2.5 Å

PDB Description: Crystal structure of the haloalcohol dehalogenase HheC complexed with (R)-styrene oxide and chloride

PDB Compounds: (A:) halohydrin dehalogenase

SCOPe Domain Sequences for d1pwza_:

Sequence; same for both SEQRES and ATOM records:

>d1pwza_ c.2.1.2 (A:) Halohydrin dehalogenase HheC {Agrobacterium tumefaciens [TaxId: 358]}
staivtnvkhfggmgsalrlseaghtvachdesfkqkdeleafaetypqlkpmseqepae
lieavtsaygqvdvlvsndifapefqpidkyavedyrgavealqirpfalvnavasqmkk
rksghiifitsatpfgpwkelstytsaragactlanalskelgeynipvfaigpnylhse
dspyfyptepwktnpehvahvkkvtalqrlgtqkelgelvaflasgscdyltgqvfwlag
gfpmierwpgmp

Timeline for d1pwza_:

• d1pwza_ first appeared in SCOP 1.67
  
• d1pwza_ appears in SCOPe 2.05
  
• d1pwza_ appears in SCOPe 2.07
  
• d1pwza_ appears in the current release, SCOPe 2.08