Lineage for d1pw6b_ (1pw6 B:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991528Family a.26.1.2: Short-chain cytokines [47286] (14 protein domains)
  6. 1991585Protein Interleukin-2 (IL-2) [47301] (1 species)
  7. 1991586Species Human (Homo sapiens) [TaxId:9606] [47302] (16 PDB entries)
  8. 1991601Domain d1pw6b_: 1pw6 B: [95201]
    complexed with a small molecule inhibitor
    complexed with frb, so4

Details for d1pw6b_

PDB Entry: 1pw6 (more details), 2.6 Å

PDB Description: Low Micromolar Small Molecule Inhibitor of IL-2
PDB Compounds: (B:) interleukin-2

SCOPe Domain Sequences for d1pw6b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1pw6b_ a.26.1.2 (B:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1pw6b_:

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Timeline for d1pw6b_: