SCOP 1.67: Domain d1pv8b_: 1pv8 B:

Lineage for d1pv8b_ (1pv8 B:)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (28 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.10: Aldolase [51569] (5 families)
   Common fold covers whole protein structure

5. Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (1 protein)
   hybrid of classes I and II aldolase

6. Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51595] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63921] (2 PDB entries)

8. Domain d1pv8b_: 1pv8 B: [95156]
   complexed with pb1, zn; mutant

Details for d1pv8b_

PDB Entry: 1pv8, 2.2 Å

PDB Description: crystal structure of a low activity f12l mutant of human porphobilinogen synthase

SCOP Domain Sequences for d1pv8b_:

Sequence, based on SEQRES records:

>d1pv8b_ c.1.10.3 (B:) 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) {Human (Homo sapiens)}
pqsvlhsgylhpllrawqtatttlnasnliypifvtdvpddiqpitslpgvarygvkrle
emlrplveeglrcvlifgvpsrvpkdergsaadseespaieaihllrktfpnllvacdvc
lcpytshghcgllsengafraeesrqrlaevalayakagcqvvapsdmmdgrveaikeal
mahglgnrvsvmsysakfascfygpfrdaaksspafgdrrcyqlppgarglalravdrdv
regadmlmvkpgmpyldivrevkdkhpdlplavyhvsgefamlwhgaqagafdlkaavle
amtafrragadiiityytpqllqwlk

Sequence, based on observed residues (ATOM records):

>d1pv8b_ c.1.10.3 (B:) 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) {Human (Homo sapiens)}
pqsvlhsgylhpllrawqtatttlnasnliypifvtdvpddiqpitslpgvarygvkrle
emlrplveeglrcvlifgvpeespaieaihllrktfpnllvacdvcafraeesrqrlaev
alayakagcqvvapsddgrveaikealmahglgnrvsvmsysakfascfygpfrdaalpp
garglalravdrdvregadmlmvkpgmpyldivrevkdkhpdlplavyhvsgefamlwhg
aqagafdlkaavleamtafrragadiiityytpqllqwlk

Timeline for d1pv8b_:

• d1pv8b_ is new in SCOP 1.67
  
• d1pv8b_ appears in SCOP 1.69
  
• d1pv8b_ appears in the current release, SCOPe 2.08