SCOP 1.73: Domain d1ptwb_: 1ptw B:

Lineage for d1ptwb_ (1ptw B:)

1. Root: SCOP 1.73

2. Class a: All alpha proteins [46456] (258 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (5 families)

5. Family a.211.1.2: PDEase [48548] (6 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase pde4d [89151] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89152] (20 PDB entries)

8. Domain d1ptwb_: 1ptw B: [95107]

Details for d1ptwb_

PDB Entry: 1ptw, 2.3 Å

PDB Description: The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis

PDB Compounds: (B:) cAMP-specific phosphodiesterase PDE4D2

SCOP Domain Sequences for d1ptwb_:

Sequence; same for both SEQRES and ATOM records:

>d1ptwb_ a.211.1.2 (B:) Catalytic domain of cyclic nucleotide phosphodiesterase pde4d {Human (Homo sapiens) [TaxId: 9606]}
teqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlity
lmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhp
gvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvi
divlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkp
lqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwa
dlvhpdaqdildtlednrewyqstipq

Timeline for d1ptwb_:

• d1ptwb_ first appeared in SCOP 1.67
  
• d1ptwb_ appears in SCOP 1.71
  
• d1ptwb_ appears in SCOP 1.75
  
• d1ptwb_ appears in the current release, SCOPe 2.08