SCOP 1.75: Domain d1pd8a_: 1pd8 A:

Lineage for d1pd8a_ (1pd8 A:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (25 PDB entries)

8. Domain d1pd8a_: 1pd8 A: [94515]
   complexed with co4, ndp

Details for d1pd8a_

PDB Entry: 1pd8, 2.1 Å

PDB Description: Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase

PDB Compounds: (A:) dihydrofolate reductase

SCOP Domain Sequences for d1pd8a_:

Sequence; same for both SEQRES and ATOM records:

>d1pd8a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d1pd8a_:

• d1pd8a_ first appeared in SCOP 1.67
  
• d1pd8a_ appears in SCOP 1.73
  
• d1pd8a_ appears in SCOPe 2.01
  
• d1pd8a_ appears in the current release, SCOPe 2.08