SCOPe 2.07: Domain d1p74b1: 1p74 B:102-272

Lineage for d1p74b1 (1p74 B:102-272)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

6. Protein Shikimate 5-dehydrogenase AroE [89538] (6 species)

7. Species Haemophilus influenzae [TaxId:727] [102173] (2 PDB entries)

8. Domain d1p74b1: 1p74 B:102-272 [94208]
   Other proteins in same PDB: d1p74a2, d1p74b2

Details for d1p74b1

PDB Entry: 1p74, 2.4 Å

PDB Description: crystal structure of shikimate dehydrogenase (aroe) from haemophilus influenzae

PDB Compounds: (B:) Shikimate 5-dehydrogenase

SCOPe Domain Sequences for d1p74b1:

Sequence, based on SEQRES records:

>d1p74b1 c.2.1.7 (B:102-272) Shikimate 5-dehydrogenase AroE {Haemophilus influenzae [TaxId: 727]}
dgiglvtdlqrlnwlrpnqhvlilgaggatkgvllpllqaqqnivlanrtfsktkelaer
fqpygniqavsmdsiplqtydlvinatsaglsggtasvdaeilklgsafydmqyakgtdt
pfialckslgltnvsdgfgmlvaqaahsfhlwrgvmpdfvsvyeqlkkaml

Sequence, based on observed residues (ATOM records):

>d1p74b1 c.2.1.7 (B:102-272) Shikimate 5-dehydrogenase AroE {Haemophilus influenzae [TaxId: 727]}
dgiglvtdlqrlnwlrpnqhvlilgaggatkgvllpllqaqqnivlanrtfsktkelaer
fqpygniqavsmdsiplqtydlvinatsaasvdaeilklgsafydmqyakgtdtpfialc
kslgltnvsdgfgmlvaqaahsfhlwrgvmpdfvsvyeqlkkaml

Timeline for d1p74b1:

• d1p74b1 first appeared in SCOP 1.67
  
• d1p74b1 appears in SCOPe 2.06
  
• d1p74b1 appears in the current release, SCOPe 2.08