SCOPe 2.05: Domain d1p4rb1: 1p4r B:5-200

Lineage for d1p4rb1 (1p4r B:5-200)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.24: Methylglyoxal synthase-like [52334] (1 superfamily)
   3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.24.1: Methylglyoxal synthase-like [52335] (3 families)
   contains a common phosphate-binding site

5. Family c.24.1.3: Inosicase [63971] (1 protein)

6. Protein IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC [63972] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102255] (3 PDB entries)

8. Domain d1p4rb1: 1p4r B:5-200 [94115]
   Other proteins in same PDB: d1p4ra2, d1p4rb2
   complexed with 354, amz, k, xmp

Details for d1p4rb1

PDB Entry: 1p4r, 2.55 Å

PDB Description: Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

PDB Compounds: (B:) Bifunctional purine biosynthesis protein PURH

SCOPe Domain Sequences for d1p4rb1:

Sequence; same for both SEQRES and ATOM records:

>d1p4rb1 c.24.1.3 (B:5-200) IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC {Human (Homo sapiens) [TaxId: 9606]}
qlalfsvsdktglvefarnltalglnlvasggtakalrdaglavrdvseltgfpemlggr
vktlhpavhagilarnipednadmarldfnlirvvacnlypfvktvaspgvtveeaveqi
diggvtllraaaknharvtvvcepedyvvvstemqsseskdtsletrrqlalkafthtaq
ydeaisdyfrkqyskg

Timeline for d1p4rb1:

• d1p4rb1 first appeared in SCOP 1.67
  
• d1p4rb1 appears in SCOPe 2.04
  
• d1p4rb1 appears in SCOPe 2.06
  
• d1p4rb1 appears in the current release, SCOPe 2.08