Lineage for d1p4ra1 (1p4r A:4-200)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2442046Fold c.24: Methylglyoxal synthase-like [52334] (1 superfamily)
    3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
  4. 2442047Superfamily c.24.1: Methylglyoxal synthase-like [52335] (4 families) (S)
    contains a common phosphate-binding site
  5. 2442137Family c.24.1.3: Inosicase [63971] (1 protein)
  6. 2442138Protein IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC [63972] (3 species)
  7. 2442160Species Human (Homo sapiens) [TaxId:9606] [102255] (3 PDB entries)
  8. 2442165Domain d1p4ra1: 1p4r A:4-200 [94113]
    Other proteins in same PDB: d1p4ra2, d1p4rb2
    complexed with 354, amz, k, xmp

Details for d1p4ra1

PDB Entry: 1p4r (more details), 2.55 Å

PDB Description: Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
PDB Compounds: (A:) Bifunctional purine biosynthesis protein PURH

SCOPe Domain Sequences for d1p4ra1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1p4ra1 c.24.1.3 (A:4-200) IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1p4ra1:

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Timeline for d1p4ra1:

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