SCOPe 2.05: Domain d1ot7a_: 1ot7 A:

Lineage for d1ot7a_ (1ot7 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Bile acid receptor FXR [101433] (2 species)

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [101435] (2 PDB entries)

8. Domain d1ot7a_: 1ot7 A: [93505]
   complexed with a co-activator peptide, chains C, D and E
   complexed with chc, iu5

Details for d1ot7a_

PDB Entry: 1ot7, 2.9 Å

PDB Description: Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR

PDB Compounds: (A:) Bile acid receptor

SCOPe Domain Sequences for d1ot7a_:

Sequence; same for both SEQRES and ATOM records:

>d1ot7a_ a.123.1.1 (A:) Bile acid receptor FXR {Norway rat (Rattus norvegicus) [TaxId: 10116]}
teltvdqqtlldyimdsyskqrmpqeitnkilkeefsaeenfliltematshvqilveft
krlpgfqtldhedqiallkgsaveamflrsaeifnkklpaghadlleerirksgisdeyi
tpmfsfyksvgelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckiy
qpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdv

Timeline for d1ot7a_:

• d1ot7a_ first appeared in SCOP 1.67
  
• d1ot7a_ appears in SCOPe 2.04
  
• d1ot7a_ appears in SCOPe 2.06
  
• d1ot7a_ appears in the current release, SCOPe 2.08