SCOPe 2.05: Domain d1osha_: 1osh A:

Lineage for d1osha_ (1osh A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Bile acid receptor FXR [101433] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101434] (7 PDB entries)

8. Domain d1osha_: 1osh A: [93496]
   complexed with fex

Details for d1osha_

PDB Entry: 1osh, 1.8 Å

PDB Description: A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

PDB Compounds: (A:) Bile acid receptor

SCOPe Domain Sequences for d1osha_:

Sequence, based on SEQRES records:

>d1osha_ a.123.1.1 (A:) Bile acid receptor FXR {Human (Homo sapiens) [TaxId: 9606]}
shgeltpdqqtllhfimdsynkqrmpqeitnkilkeefsaeenfliltematnhvqvlve
ftkklpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdlleerirnsgisde
yitpmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklck
ihqpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdv

Sequence, based on observed residues (ATOM records):

>d1osha_ a.123.1.1 (A:) Bile acid receptor FXR {Human (Homo sapiens) [TaxId: 9606]}
shgeltpdqqtllhfimdsynkqrmpenfliltematnhvqvlveftkklpgfqtldhed
qiallkgsaveamflrsaeifnkklpsghsdlleerirnsgisdeyitpmfsfyksigel
kmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckihqpenpqhfacllg
rltelrtfnhhhaemlmswrvndhkftpllceiwdv

Timeline for d1osha_:

• d1osha_ first appeared in SCOP 1.67
  
• d1osha_ appears in SCOPe 2.04
  
• d1osha_ is called d1osha1 in SCOPe 2.06
  
• d1osha_ appears in the current release, SCOPe 2.08, called d1osha1