SCOPe 2.08: Domain d1olxa_: 1olx A:

Lineage for d1olxa_ (1olx A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88768] (19 PDB entries)
   Uniprot P12694 52-445

8. Domain d1olxa_: 1olx A: [93338]
   Other proteins in same PDB: d1olxb1, d1olxb2
   complexed with gol, k, mn, tdp

Details for d1olxa_

PDB Entry: 1olx, 2.25 Å

PDB Description: roles of his291-alpha and his146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase

PDB Compounds: (A:) 2-oxoisovalerate dehydrogenase alpha subunit

SCOPe Domain Sequences for d1olxa_:

Sequence, based on SEQRES records:

>d1olxa_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
dkpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksm
tllntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdy
plelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakranan
rvvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargp
gygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrsvd
evnywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllf
sdvyqempaqlrkqqeslarhlqtygehypldhfdk

Sequence, based on observed residues (ATOM records):

>d1olxa_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
dkpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksm
tllntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdy
plelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakranan
rvvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargp
gygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrnyw
dkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyq
empaqlrkqqeslarhlqtygehypldhfdk

Timeline for d1olxa_:

• d1olxa_ first appeared in SCOP 1.67
  
• d1olxa_ appears in SCOPe 2.07