Lineage for d1olxa_ (1olx A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108723Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 2108727Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)
  7. 2108728Species Human (Homo sapiens) [TaxId:9606] [88768] (19 PDB entries)
    Uniprot P12694 52-445
  8. 2108746Domain d1olxa_: 1olx A: [93338]
    Other proteins in same PDB: d1olxb1, d1olxb2
    complexed with gol, k, mn, tdp

Details for d1olxa_

PDB Entry: 1olx (more details), 2.25 Å

PDB Description: roles of his291-alpha and his146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase
PDB Compounds: (A:) 2-oxoisovalerate dehydrogenase alpha subunit

SCOPe Domain Sequences for d1olxa_:

Sequence, based on SEQRES records: (download)

>d1olxa_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
dkpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksm
tllntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdy
plelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakranan
rvvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargp
gygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrsvd
evnywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllf
sdvyqempaqlrkqqeslarhlqtygehypldhfdk

Sequence, based on observed residues (ATOM records): (download)

>d1olxa_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
dkpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksm
tllntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdy
plelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakranan
rvvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargp
gygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrnyw
dkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyq
empaqlrkqqeslarhlqtygehypldhfdk

SCOPe Domain Coordinates for d1olxa_:

Click to download the PDB-style file with coordinates for d1olxa_.
(The format of our PDB-style files is described here.)

Timeline for d1olxa_: