SCOP 1.73: Domain d1olua_: 1olu A:

Lineage for d1olua_ (1olu A:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (4 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88768] (18 PDB entries)

8. Domain d1olua_: 1olu A: [93335]
   Other proteins in same PDB: d1olub1, d1olub2
   complexed with gol, k, mg, tdp; mutant

Details for d1olua_

PDB Entry: 1olu, 1.9 Å

PDB Description: roles of his291-alpha and his146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase

PDB Compounds: (A:) 2-oxoisovalerate dehydrogenase alpha subunit

SCOP Domain Sequences for d1olua_:

Sequence, based on SEQRES records:

>d1olua_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
pqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmtl
lntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdypl
elfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananrv
vicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpgy
gimsirvdgndvfavynatkearrravaenqpflieamtyrighastsddssayrsvdev
nywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsd
vyqempaqlrkqqeslarhlqtygehypldhfdk

Sequence, based on observed residues (ATOM records):

>d1olua_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
pqfpgasaefidklefiqpngipiyrvmdrqgqiinpsedphlpkekvlklyksmtllnt
mdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdyplelf
maqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananrvvic
yfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpgygim
sirvdgndvfavynatkearrravaenqpflieamtyrdhpisrlrhyllsqgwwdeeqe
kawrkqsrrkvmeafeqaerkpkpnpnllfsdvyqempaqlrkqqeslarhlqtygehyp
ldhfdk

Timeline for d1olua_:

• d1olua_ first appeared in SCOP 1.67
  
• d1olua_ appears in SCOP 1.71
  
• d1olua_ appears in SCOP 1.75
  
• d1olua_ appears in the current release, SCOPe 2.08