SCOP 1.75: Domain d1nrla_: 1nrl A:

Lineage for d1nrla_ (1nrl A:)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (33 proteins)

6. Protein Pregnane x receptor, PXR [63624] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63625] (6 PDB entries)

8. Domain d1nrla_: 1nrl A: [92091]
   complexed with an src-1 coactivator peptide and sr12813

Details for d1nrla_

PDB Entry: 1nrl, 2 Å

PDB Description: Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813

PDB Compounds: (A:) orphan nuclear receptor pxr

SCOP Domain Sequences for d1nrla_:

Sequence, based on SEQRES records:

>d1nrla_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsq
vrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvi
syfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqllle
pmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnr
pqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgitg

Sequence, based on observed residues (ATOM records):

>d1nrla_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvsreeaakwsqvrkdlcslkvslql
rgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisl
lkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqlllepmlkfhymlkklql
heeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkima
mltelrsinaqhtqrllriqdihpfatplmqelfgitg

Timeline for d1nrla_:

• d1nrla_ first appeared in SCOP 1.67
  
• d1nrla_ appears in SCOP 1.73
  
• d1nrla_ appears in SCOPe 2.01
  
• d1nrla_ appears in the current release, SCOPe 2.08