SCOP 1.75: Domain d1nm6a_: 1nm6 A:

Lineage for d1nm6a_ (1nm6 A:)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (164 PDB entries)
   Uniprot P00734 331-361,364-421
   Uniprot P00734 334-360 364-510 518-619
   Uniprot P00734 328-620
   Uniprot P00734 355-621
   Uniprot P00734 328-620
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1nm6a_: 1nm6 A: [91973]
   complexed with l86

Details for d1nm6a_

PDB Entry: 1nm6, 1.8 Å

PDB Description: thrombin in complex with selective macrocyclic inhibitor at 1.8a

PDB Compounds: (A:) thrombin

SCOP Domain Sequences for d1nm6a_:

Sequence, based on SEQRES records:

>d1nm6a_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspqellcgas
lisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpryn
wrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtan
vgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvm
kspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfg

Sequence, based on observed residues (ATOM records):

>d1nm6a_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyiivegsdaeigmspwqvmlfrkspqellcgaslis
drwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwre
nldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsvlqv
vnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqm
givswgegcdrdgkygfythvfrlkkwiqkvidqfg

Timeline for d1nm6a_:

• d1nm6a_ first appeared in SCOP 1.67
  
• d1nm6a_ appears in SCOP 1.73
  
• d1nm6a_ appears in SCOPe 2.01
  
• d1nm6a_ appears in the current release, SCOPe 2.08