SCOPe 2.02: Domain d1nj9h1: 1nj9 H:1-113

Lineage for d1nj9h1 (1nj9 H:1-113)

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (152 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1nj9h1: 1nj9 H:1-113 [91901]
   Other proteins in same PDB: d1nj9a1, d1nj9a2, d1nj9b2, d1nj9h2, d1nj9l1, d1nj9l2
   part of cocaine hydrolytic Fab 15a10
   complexed with na

Details for d1nj9h1

PDB Entry: 1nj9, 2.35 Å

PDB Description: cocaine hydrolytic antibody 15a10

PDB Compounds: (H:) immunoglobulin heavy chain

SCOPe Domain Sequences for d1nj9h1:

Sequence; same for both SEQRES and ATOM records:

>d1nj9h1 b.1.1.1 (H:1-113) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
evqlqqsgpelvkpgasvkvsckasgysftdynmywvkqnhgeslewiayidpsngdtfy
nqkfqgkatvtldkssstafmhlnsltsedsavyycarggglfafwgqgtlvtvsa

Timeline for d1nj9h1:

• d1nj9h1 first appeared in SCOP 1.67
  
• d1nj9h1 appears in SCOPe 2.01
  
• d1nj9h1 appears in SCOPe 2.03
  
• d1nj9h1 appears in the current release, SCOPe 2.08