SCOPe 2.08: Domain d1nfbb1: 1nfb B:10-111,B:232-498

Lineage for d1nfbb1 (1nfb B:10-111,B:232-498)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (2 families)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

7. Species Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)

8. Domain d1nfbb1: 1nfb B:10-111,B:232-498 [91861]
   Other proteins in same PDB: d1nfba4, d1nfbb4
   complexed with cpr, nad

Details for d1nfbb1

PDB Entry: 1nfb, 2.9 Å

PDB Description: Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD

PDB Compounds: (B:) Inosine-5'-monophosphate dehydrogenase 2

SCOPe Domain Sequences for d1nfbb1:

Sequence, based on SEQRES records:

>d1nfbb1 c.1.5.1 (B:10-111,B:232-498) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamdkhlssqn
ryfseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgel
kfekrtssaq

Sequence, based on observed residues (ATOM records):

>d1nfbb1 c.1.5.1 (B:10-111,B:232-498) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmdkgsihkfvpylia
giqhscqdigaksltqvrammysgelkfekrtssaq

Timeline for d1nfbb1:

• d1nfbb1 first appeared in SCOP 1.67
  
• d1nfbb1 appears in SCOPe 2.07