SCOP 1.73: Domain d1nf7b1: 1nf7 B:10-111,B:232-514

Lineage for d1nf7b1 (1nf7 B:10-111,B:232-514)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (1 family)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (6 species)

7. Species Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)

8. Domain d1nf7b1: 1nf7 B:10-111,B:232-514 [91855]
   Other proteins in same PDB: d1nf7a2, d1nf7a3, d1nf7b2, d1nf7b3
   complexed with k, myd, rvp

Details for d1nf7b1

PDB Entry: 1nf7, 2.65 Å

PDB Description: Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide

PDB Compounds: (B:) Inosine-5'-monophosphate dehydrogenase 2

SCOP Domain Sequences for d1nf7b1:

Sequence, based on SEQRES records:

>d1nf7b1 c.1.5.1 (B:10-111,B:232-514) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamdkhlssqn
ryfseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgel
kfekrtssaqveggvhslhsyekrlf

Sequence, based on observed residues (ATOM records):

>d1nf7b1 c.1.5.1 (B:10-111,B:232-514) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamikvaqgvs
gavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgelkfekrtssaqveggvh
slhsyekrlf

Timeline for d1nf7b1:

• d1nf7b1 first appeared in SCOP 1.67
  
• d1nf7b1 appears in SCOP 1.71
  
• d1nf7b1 appears in SCOP 1.75
  
• d1nf7b1 appears in the current release, SCOPe 2.08