SCOPe 2.07: Domain d1nf7a1: 1nf7 A:10-111,A:232-514

Lineage for d1nf7a1 (1nf7 A:10-111,A:232-514)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (2 families)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

7. Species Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)

8. Domain d1nf7a1: 1nf7 A:10-111,A:232-514 [91852]
   Other proteins in same PDB: d1nf7a4, d1nf7b4
   complexed with k, myd, rvp, unk

Details for d1nf7a1

PDB Entry: 1nf7, 2.65 Å

PDB Description: Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide

PDB Compounds: (A:) Inosine-5'-monophosphate dehydrogenase 2

SCOPe Domain Sequences for d1nf7a1:

Sequence, based on SEQRES records:

>d1nf7a1 c.1.5.1 (A:10-111,A:232-514) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamdkhlssqn
ryfseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgel
kfekrtssaqveggvhslhsyekrlf

Sequence, based on observed residues (ATOM records):

>d1nf7a1 c.1.5.1 (A:10-111,A:232-514) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamikvaqgvs
gavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgelkfekrtssaqveggvh
slhsyekrlf

Timeline for d1nf7a1:

• d1nf7a1 first appeared in SCOP 1.67
  
• d1nf7a1 appears in SCOPe 2.06
  
• d1nf7a1 appears in the current release, SCOPe 2.08