SCOP 1.75: Domain d1nc2b1: 1nc2 B:1-120

Lineage for d1nc2b1 (1nc2 B:1-120)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 5 [TaxId:10090] [88555] (36 PDB entries)

8. Domain d1nc2b1: 1nc2 B:1-120 [91783]
   Other proteins in same PDB: d1nc2a1, d1nc2a2, d1nc2b2, d1nc2c1, d1nc2c2, d1nc2d2
   part of Fab 2d12.5

Details for d1nc2b1

PDB Entry: 1nc2, 2.1 Å

PDB Description: crystal structure of monoclonal antibody 2d12.5 fab complexed with y- dota

PDB Compounds: (B:) monoclonal antibody 2d12.5, igg1 gamma heavy chain

SCOP Domain Sequences for d1nc2b1:

Sequence; same for both SEQRES and ATOM records:

>d1nc2b1 b.1.1.1 (B:1-120) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 5 [TaxId: 10090]}
evklqesgpglvqpsqslsitctvsgfsltdygvhwvrqspgkglewlgviwsgggtayt
aafisrlniykdnsknqvffemnslqandtamyycarrgsypynyfdvwgqgttvtvssa

Timeline for d1nc2b1:

• d1nc2b1 first appeared in SCOP 1.67
  
• d1nc2b1 appears in SCOP 1.73
  
• d1nc2b1 appears in SCOPe 2.01
  
• d1nc2b1 appears in the current release, SCOPe 2.08