SCOPe 2.05: Domain d1n2ka_: 1n2k A:

Lineage for d1n2ka_ (1n2k A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.76: Alkaline phosphatase-like [53648] (1 superfamily)
   core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest

4. Superfamily c.76.1: Alkaline phosphatase-like [53649] (6 families)

5. Family c.76.1.2: Arylsulfatase [53653] (4 proteins)
   includes additional C-terminal alpha+beta (sub)domain

6. Protein Arylsulfatase A [53654] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53655] (7 PDB entries)

8. Domain d1n2ka_: 1n2k A: [91559]
   covalent reaction intermediate
   complexed with ca, ndg

Details for d1n2ka_

PDB Entry: 1n2k, 2.75 Å

PDB Description: crystal structure of a covalent intermediate of endogenous human arylsulfatase a

PDB Compounds: (A:) arylsulfatase a

SCOPe Domain Sequences for d1n2ka_:

Sequence, based on SEQRES records:

>d1n2ka_ c.76.1.2 (A:) Arylsulfatase A {Human (Homo sapiens) [TaxId: 9606]}
rppnivlifaddlgygdlgcyghpssttpnldqlaagglrftdfyvpvslstpsraallt
grlpvrmgmypgvlvpssrgglpleevtvaevlaargyltgmagkwhlgvgpegaflpph
qgfhrflgipyshdqgpcqnltcfppatpcdggcdqglvpipllanlsveaqppwlpgle
arymafahdlmadaqrqdrpfflyyashhthypqfsgqsfaersgrgpfgdslmeldaav
gtlmtaigdlglleetlviftadngpetmrmsrggcsgllrcgkgttyeggvrepalafw
pghiapgvthelassldllptlaalagaplpnvtldgfdlsplllgtgksprqslffyps
ypdevrgvfavrtgkykahfftqgsahsdttadpachasssltaheppllydlskdpgen
ynllggvagatpevlqalkqlqllkaqldaavtfgpsqvargedpalqicchpgctprpa
cchcpd

Sequence, based on observed residues (ATOM records):

>d1n2ka_ c.76.1.2 (A:) Arylsulfatase A {Human (Homo sapiens) [TaxId: 9606]}
rppnivlifaddlgygdlgcyghpssttpnldqlaagglrftdfyvpvslstpsraallt
grlpvrmgmypgvlvpssrgglpleevtvaevlaargyltgmagkwhlgvgpegaflpph
qgfhrflgipyshdqgpcqnltcfppatpcdggcdqglvpipllanlsveaqppwlpgle
arymafahdlmadaqrqdrpfflyyashhthypqfsgqsfaersgrgpfgdslmeldaav
gtlmtaigdlglleetlviftadngpetmrmsrggcsgllrcgkgttyeggvrepalafw
pghiapgvthelassldllptlaalagaplpnvtldgfdlsplllgtgksprqslffyps
ypdevrgvfavrtgkykahfftqgsahsdttadpachasssltaheppllydlskdpgen
ynllgatpevlqalkqlqllkaqldaavtfgpsqvargedpalqicchpgctprpacchc
pd

Timeline for d1n2ka_:

• d1n2ka_ first appeared in SCOP 1.67
  
• d1n2ka_ appears in SCOPe 2.04
  
• d1n2ka_ appears in SCOPe 2.06
  
• d1n2ka_ appears in the current release, SCOPe 2.08