SCOPe 2.02: Domain d1mxfd_: 1mxf D:

Lineage for d1mxfd_ (1mxf D:)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

7. Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)

8. Domain d1mxfd_: 1mxf D: [91489]
   complexed with mtx, ndp

Details for d1mxfd_

PDB Entry: 1mxf, 2.3 Å

PDB Description: crystal structure of inhibitor complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi

PDB Compounds: (D:) pteridine reductase 2

SCOPe Domain Sequences for d1mxfd_:

Sequence, based on SEQRES records:

>d1mxfd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma cruzi [TaxId: 5693]}
cpaavitggarrighsiavrlhqqgfrvvvhyrhsegaaqrlvaelnaaragsavlckgd
lslssslldccediidcsfrafgrcdvlvnnasayyptpllpgddtngaadakpidaqva
elfgsnavaplflirafarrqgeggawrsrnlsvvnlcdamtdlplpgfcvytmakhalg
gltraaalelaprhirvnavapglsllppampqetqeeyrrkvplgqseasaaqiadaia
flvskdagyitgttlkvdgglilara

Sequence, based on observed residues (ATOM records):

>d1mxfd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma cruzi [TaxId: 5693]}
cpaavitggarrighsiavrlhqqgfrvvvhyrhsegaaqrlvaelnaaragsavlckgd
lslssslldccediidcsfrafgrcdvlvnnasayyptpllpkpidaqvaelfgsnavap
lflirafarrqnlsvvnlcdamtdlplpgfcvytmakhalggltraaalelaprhirvna
vapglsllppampqetqeeyrrkvplgqseasaaqiadaiaflvskdagyitgttlkvdg
glilara

Timeline for d1mxfd_:

• d1mxfd_ first appeared in SCOP 1.67
  
• d1mxfd_ appears in SCOPe 2.01
  
• d1mxfd_ appears in SCOPe 2.03
  
• d1mxfd_ appears in the current release, SCOPe 2.08