SCOP 1.75: Domain d1mxfb_: 1mxf B:

Lineage for d1mxfb_ (1mxf B:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

7. Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)

8. Domain d1mxfb_: 1mxf B: [91487]

Details for d1mxfb_

PDB Entry: 1mxf, 2.3 Å

PDB Description: crystal structure of inhibitor complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi

PDB Compounds: (B:) pteridine reductase 2

SCOP Domain Sequences for d1mxfb_:

Sequence, based on SEQRES records:

>d1mxfb_ c.2.1.2 (B:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma cruzi [TaxId: 5693]}
cpaavitggarrighsiavrlhqqgfrvvvhyrhsegaaqrlvaelnaaragsavlckgd
lslssslldccediidcsfrafgrcdvlvnnasayyptpllpgddtngaadakpidaqva
elfgsnavaplflirafarrqgeggawrsrnlsvvnlcdamtdlplpgfcvytmakhalg
gltraaalelaprhirvnavapglsllppampqetqeeyrrkvplgqseasaaqiadaia
flvskdagyitgttlkvdgglilara

Sequence, based on observed residues (ATOM records):

>d1mxfb_ c.2.1.2 (B:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma cruzi [TaxId: 5693]}
cpaavitggarrighsiavrlhqqgfrvvvhyrhsegaaqrlvaelnaaragsavlckgd
lslssslldccediidcsfrafgrcdvlvnnasayyptpllpkpidaqvaelfgsnavap
lflirafarrqnlsvvnlcdamtdlplpgfcvytmakhalggltraaalelaprhirvna
vapglsllppampqetqeeyrrkvplgqseasaaqiadaiaflvskdagyitgttlkvdg
glilara

Timeline for d1mxfb_:

• d1mxfb_ first appeared in SCOP 1.67
  
• d1mxfb_ appears in SCOP 1.73
  
• d1mxfb_ appears in SCOPe 2.01
  
• d1mxfb_ appears in the current release, SCOPe 2.08