SCOPe 2.05: Domain d1meia1: 1mei A:2-101,A:222-483

Lineage for d1meia1 (1mei A:2-101,A:222-483)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (2 families)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

7. Species Tritrichomonas foetus [TaxId:5724] [51417] (9 PDB entries)

8. Domain d1meia1: 1mei A:2-101,A:222-483 [91251]
   there two CBS domains in the disordered region 102-221
   complexed with k, moa, xmp

Details for d1meia1

PDB Entry: 1mei, 2.2 Å

PDB Description: Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and mycophenolic acid bound

PDB Compounds: (A:) inosine-5'-monophosphate dehydrogenase

SCOPe Domain Sequences for d1meia1:

Sequence, based on SEQRES records:

>d1meia1 c.1.5.1 (A:2-101,A:222-483) Inosine monophosphate dehydrogenase (IMPDH) {Tritrichomonas foetus [TaxId: 5724]}
akyynepchtfneyllipglstvdcipsnvnlstplvkfqkgqqseinlkiplvsaimqs
vsgekmaialareggisfifgsqsiesqaamvhavknfkaXhnelvdsqkrylvgagint
rdfrervpalveagadvlcidssdgfsewqkitigwirekygdkvkvgagnivdgegfry
ladagadfikigigggsicitreqkgigrgqatavidvvaernkyfeetgiyipvcsdgg
ivydyhmtlalamgadfimlgryfarfeesptrkvtingsvmkeywgegssrarnwqryd
lggkqklsfeegvdsyvpyagklkdnveaslnkvkstmcncgaltipqlqskakitlvss
vsi

Sequence, based on observed residues (ATOM records):

>d1meia1 c.1.5.1 (A:2-101,A:222-483) Inosine monophosphate dehydrogenase (IMPDH) {Tritrichomonas foetus [TaxId: 5724]}
akyynepchtfneyllipglstvdcipsnvnlstplvkfqkgqqseinlkiplvsaimqs
vsgekmaialareggisfifgsqsiesqaamvhavknfkaXhnelvdsqkrylvgagint
rdfrervpalveagadvlcidssdgfsewqkitigwirekygdkvkvgagnivdgegfry
ladagadfikigigggsicitreqkgigrgqatavidvvaernkyfeetgiyipvcsdgg
ivydyhmtlalamgadfimlgryfarfeesptrkvtingsvmkeywgegssrarnwsfee
gvdsyvpyagklkdnveaslnkvkstmcncgaltipqlqskakitlvssvsi

Timeline for d1meia1:

• d1meia1 first appeared in SCOP 1.67
  
• d1meia1 appears in SCOPe 2.04
  
• d1meia1 appears in SCOPe 2.06
  
• d1meia1 appears in the current release, SCOPe 2.08