SCOPe 2.06: Domain d1md8a1: 1md8 A:434-686

Lineage for d1md8a1 (1md8 A:434-686)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Complement C1R protease, catalytic domain [74976] (1 species)
7. Species Human (Homo sapiens) [TaxId:9606] [74977] (3 PDB entries)

8. Domain d1md8a1: 1md8 A:434-686 [91245]
   Other proteins in same PDB: d1md8a2

Details for d1md8a1

PDB Entry: 1md8, 2.8 Å

PDB Description: Monomeric structure of the active catalytic domain of complement protease C1r

PDB Compounds: (A:) c1r complement serine protease

SCOPe Domain Sequences for d1md8a1:

Sequence, based on SEQRES records:

>d1md8a1 b.47.1.2 (A:434-686) Complement C1R protease, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
cgkpvnpveqrqriiggqkakmgnfpwqvftnihgrgggallgdrwiltaahtlypkehe
aqsnasldvflghtnveelmklgnhpirrvsvhpdyrqdesynfegdiallelensvtlg
pnllpiclpdndtfydlglmgyvsgfgvmeekiahdlrfvrlpvanpqacenwlrgknrm
dvfsqnmfcaghpslkqdacqgdsggvfavrdpntdrwvatgivswgigcsrgygfytkv
lnyvdwikkemee

Sequence, based on observed residues (ATOM records):

>d1md8a1 b.47.1.2 (A:434-686) Complement C1R protease, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
cgkpvnpveqriiggqkakmgnfpwqvftnihgrgggallgdrwiltaahtlypkehasl
dvflghtnveelmklgnhpirrvsvhpdyrqdesynfegdiallelensvtlgpnllpic
lpdndtfydlglmgyvsgfgvmeekiahdlrfvrlpvanpqacenwlrgknrmdvfsqnm
fcaghpslkqdacqgdsggvfavrdpntdrwvatgivswgigcsrgygfytkvlnyvdwi
kkemee

Timeline for d1md8a1:

• d1md8a1 first appeared in SCOP 1.67
  
• d1md8a1 appears in SCOPe 2.05
  
• d1md8a1 appears in SCOPe 2.07
  
• d1md8a1 appears in the current release, SCOPe 2.08