SCOP 1.69: Domain d1j2fb_: 1j2f B:

Lineage for d1j2fb_ (1j2f B:)

1. Root: SCOP 1.69

2. Class b: All beta proteins [48724] (144 folds)

3. Fold b.26: SMAD/FHA domain [49878] (1 superfamily)
   sandwich; 11 strands in 2 sheets; greek-key

4. Superfamily b.26.1: SMAD/FHA domain [49879] (3 families)
   has a few short helices inserted in loops

5. Family b.26.1.3: Interferon regulatory factor 3 (IRF3), transactivation domain [101630] (1 protein)
   weak sequence similarity to SMAD domain

6. Protein Interferon regulatory factor 3 (IRF3), transactivation domain [101631] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101632] (2 PDB entries)

8. Domain d1j2fb_: 1j2f B: [90786]

Details for d1j2fb_

PDB Entry: 1j2f, 2.3 Å

PDB Description: X-ray crystal structure of IRF-3 and its functional implications

SCOP Domain Sequences for d1j2fb_:

Sequence, based on SEQRES records:

>d1j2fb_ b.26.1.3 (B:) Interferon regulatory factor 3 (IRF3), transactivation domain {Human (Homo sapiens)}
enplkrllvpgeewefevtafyrgrqvfqqtiscpeglrlvgsevgdrtlpgwpvtlpdp
gmsltdrgvmsyvrhvlsclggglalwragqwlwaqrlghchtywavseellpnsghgpd
gevpkdkeggvfdlgpfivdlitftegsgrspryalwfcvgeswpqdqpwtkrlvmvkvv
ptclralvemarvggasslentvdlhisnshplsltsdqykaylqdlvegmdfq

Sequence, based on observed residues (ATOM records):

>d1j2fb_ b.26.1.3 (B:) Interferon regulatory factor 3 (IRF3), transactivation domain {Human (Homo sapiens)}
enplkrllvpgeewefevtafyrgrqvfqqtiscpeglrlvgsevtlpgwpvtlpdpgms
ltdrgvmsyvrhvlsclggglalwragqwlwaqrlghchtywavseellpnsghgpdgev
pkdkeggvfdlgpfivdlitftegsgrspryalwfcvgeswpqdqpwtkrlvmvkvvptc
lralvemarvggasslentvdlhisnshplsltsdqykaylqdlvegmdfq

Timeline for d1j2fb_:

• d1j2fb_ first appeared in SCOP 1.67
  
• d1j2fb_ appears in SCOP 1.71
  
• d1j2fb_ appears in the current release, SCOPe 2.08