SCOPe 2.08: Domain d1j1wa_: 1j1w A:

Lineage for d1j1wa_ (1j1w A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)

8. Domain d1j1wa_: 1j1w A: [90772]
   complexed with nap

Details for d1j1wa_

PDB Entry: 1j1w, 3.2 Å

PDB Description: Crystal Structure Of The Monomeric Isocitrate Dehydrogenase In Complex With NADP+

PDB Compounds: (A:) isocitrate dehydrogenase

SCOPe Domain Sequences for d1j1wa_:

Sequence; same for both SEQRES and ATOM records:

>d1j1wa_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Pig (Sus scrofa) [TaxId: 9823]}
tpkiiytltdeapalatysllpiikaftgssgiavetrdislagrliatfpeyltdtqki
sddlaelgklattpdaniiklpnisasvpqlkaaikelqqqgyklpdypeepktdtekdv
karydkikgsavnpvlregnsdrraplsvknyarkhphkmgawsadskshvahmdngdfy
gsekaaligapgsvkieliakdgsstvlkaktsvqageiidssvmsknalrnfiaaeied
akkqgvllsvhlkatmmkvsdpimfgqivsefykdaltkhaevlkqigfdvnngigdlya
riktlpeakqkeieadiqavyaqrpqlamvnsdkgitnlhvpsdvivdasmpamirdsgk
mwgpdgklhdtkavipdrcyagvyqvviedckqhgafdpttmgsvpnvglmaqkaeeygs
hdktfqipadgvvrvtdesgkllleqsveagdiwrmcqakdapiqdwvklavnraratnt
pavfwldparahdaqviakverylkdydtsgldirilspveatrfslariregkdtisvt
gnvlrdyltdlfpimelgtsakmlsivplmsggglfetgaggsapkhvqqfleegylrwd
slgeflalaaslehlgnayknpkalvlastldqatgkildnnksparkvgeidnrgshfy
lalywaqalaaqtedkelqaqftgiakaltdnetkivgelaaaqgkpvdiagyyhpntdl
tskamrpsatfnaalapl

Timeline for d1j1wa_:

• d1j1wa_ first appeared in SCOP 1.67
  
• d1j1wa_ appears in SCOPe 2.07