SCOP 1.75: Domain d1m2wb4: 1m2w B:1-286

Lineage for d1m2wb4 (1m2w B:1-286)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (18 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

6. Protein Mannitol 2-dehydrogenase [82301] (1 species)

7. Species Pseudomonas fluorescens [TaxId:294] [82302] (2 PDB entries)

8. Domain d1m2wb4: 1m2w B:1-286 [90397]
   Other proteins in same PDB: d1m2wa3, d1m2wb3
   complexed with mse, mtl, nad

Details for d1m2wb4

PDB Entry: 1m2w, 1.8 Å

PDB Description: Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and D-mannitol

PDB Compounds: (B:) mannitol dehydrogenase

SCOP Domain Sequences for d1m2wb4:

Sequence; same for both SEQRES and ATOM records:

>d1m2wb4 c.2.1.6 (B:1-286) Mannitol 2-dehydrogenase {Pseudomonas fluorescens [TaxId: 294]}
mklnkqnltqlapevklpaytladtrqgiahigvggfhrahqayytdalmntgegldwsi
cgvglrsedrkarddlagqdylftlyelgdtddtevrvigsisdmllaedsaqalidkla
speirivsltiteggyciddsngefmahlpqiqhdlahpsspktvfgficaaltqrraag
ipaftvmscdnlphngavtrkallafaalhnaelhdwikahvsfpnamvdritpmtstah
rlqlhdehgiddawpvvcepfvqwvledkfvngrpawekvgvqftd

Timeline for d1m2wb4:

• d1m2wb4 first appeared in SCOP 1.67
  
• d1m2wb4 appears in SCOP 1.73
  
• d1m2wb4 appears in SCOPe 2.01
  
• d1m2wb4 appears in the current release, SCOPe 2.08