Lineage for Protein: Amyloid beta precursor protein-binding protein 1, APPBP1

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2149982Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 2149983Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 2149990Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 protein domains)
    the common fold is elaborated with additional (sub)domains
  6. 2149991Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

Species:

More info for Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA)

Timeline for Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA):

  • Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA) first appeared in SCOP 1.65
  • Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA) appears in SCOPe 2.05