Class c: Alpha and beta proteins (a/b) [51349] (121 folds) |
Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily) 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest |
Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (2 families) transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds |
Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins) the common fold is elaborated with additional (sub)domains |
Protein UBA3 [89764] (1 species) a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered) |
Species Human (Homo sapiens) [TaxId:9606] [89765] (1 PDB entry) |
Domain d1ngvb_: 1ngv B: [85699] Other proteins in same PDB: d1ngva_, d1ngvc_ |
Domain d1ngvd_: 1ngv D: [85701] Other proteins in same PDB: d1ngva_, d1ngvc_ complexed with zn |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3: